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Within this review, for the 1st time we investigated the results of IOs on osteoblasts and osteoclasts activity. Also, we executed the co-culture assessments applying macrophages to verify if IOs in magnetic industry promotes M1 or either M2 macrophages polarization. As IOs might be easily synthesizable and integrate into chosen scaffolds, they may be used in numerous biomedical applications including the cure of osteoporosis. On this foundation, we have investigated the ability of IOs to induce osteoinduction and inhibit osteoclasts activity.
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